2. Signaling Pathways
  3. PROTAC
  4. PROTAC Linkers

PROTAC Linkers

PROTAC Linkers

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PROTACs (Proteolysis Targeting Chimeric Molecules) are heterobifunctional protein degraders and promising targeted therapeutics candidates for cancer. The PROTAC linker connects two functional motifs of a PROTAC, a target protein binder and an E3 ligase recruiter.

The linker plays an important role in a PROTAC. The features of the linker (type, length, attachment position) can affect the formation of ligase:PROTAC:target ternary complex, resulting in influencing the efficient ubiquitination of the target protein and its ultimate degradation. The optimal lengths of the PROTAC linkers are reported varying from 12-carbon to over 20-carbon, and the commonly used linkers in the development of PROTACs are PEGs, Alkyl-Chain and Alkyl/ether.

PROTAC Linkers Isoform Specific Products:

PROTAC Linkers Isoform Comparison
Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-175458
    Boc-piperidine-oxopiperidin 3078378-93-2
    Boc-piperidine-oxopiperidin is a PROTAC linker. Boc-piperidine-oxopiperidin can be used to synthesize PROTAC LYA914 (HY-175455).
    Boc-piperidine-oxopiperidin
  • HY-140191
    Amino-PEG4-(CH2)3CO2H 144598-03-8
    Amino-PEG4-(CH2)3CO2H is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Amino-PEG4-(CH2)3CO2H
  • HY-138716
    m-PEG9-azide 1354521-95-1
    m-PEG9-azide is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. m-PEG9-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    m-PEG9-azide
  • HY-140277
    DBCO-PEG2-PFP ester 2304558-23-2
    DBCO-PEG2-PFP ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. DBCO-PEG2-PFP ester is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.
    DBCO-PEG2-PFP ester
  • HY-W092895
    Cyclohexane-PEG1-Br 131665-94-6
    Cyclohexane-PEG1-Br is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Cyclohexane-PEG1-Br
  • HY-134713
    Tos-PEG14-OH 2987966-48-1
    Tos-PEG14-OH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Tos-PEG14-OH
  • HY-140164
    Azido-PEG2-C2-sulfonic acid 1817735-39-9
    Azido-PEG2-C2-sulfonic acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Azido-PEG2-C2-sulfonic acid is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Azido-PEG2-C2-sulfonic acid
  • HY-140333
    Diethyl 10-bromodecylphosphonate 272785-01-0
    Diethyl 10-bromodecylphosphonate is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs.
    Diethyl 10-bromodecylphosphonate
  • HY-138491
    Iodoacetyl-PEG4-biotin
    Iodoacetyl-PEG4-biotin is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Iodoacetyl-PEG4-biotin
  • HY-140202
    Amino-PEG9-amido-C16-Boc
    Amino-PEG9-amido-C16-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Amino-PEG9-amido-C16-Boc
  • HY-W096099
    Nonylbenzene-PEG8-OH 41506-14-3
    Nonylbenzene-PEG8-OH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Nonylbenzene-PEG8-OH
  • HY-130906
    DSPE-PEG46-N3
    DSPE-PEG46-N3 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. DSPE-PEG46-N3 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    DSPE-PEG46-N3
  • HY-134692
    Azido-C1-PEG3-C3-NH2 1162336-72-2
    Azido-C1-PEG3-C3-NH2 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Azido-C1-PEG3-C3-NH2 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Azido-C1-PEG3-C3-NH2
  • HY-141241
    Hydroxy-PEG3-C2-methyl ester 2086688-97-1
    Hydroxy-PEG3-C2-methyl ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Hydroxy-PEG3-C2-methyl ester
  • HY-140816
    Azido-PEG2-hydrazide-Boc 2100306-56-5
    Azido-PEG2-hydrazide-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Azido-PEG2-hydrazide-Boc is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Azido-PEG2-hydrazide-Boc
  • HY-132082
    Benzyl-PEG13-azide
    Benzyl-PEG13-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Benzyl-PEG13-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Benzyl-PEG13-azide
  • HY-140686
    m-PEG2000-CH2COOH
    m-PEG2000-CH2COOH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    m-PEG2000-CH2COOH
  • HY-117041
    m-PEG4-CH2-aldehyde 1059189-65-9
    m-PEG4-CH2-aldehyde is a PEG-based based PROTAC linker can be used in the synthesis of PROTACs.
    m-PEG4-CH2-aldehyde
  • HY-140361
    m-PEG11-Tos
    m-PEG11-Tos is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    m-PEG11-Tos
  • HY-134690
    Propanol-PEG4-CH2OH 156868-17-6
    Propanol-PEG4-CH2OH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Propanol-PEG4-CH2OH
PROTAC Linkers Isoform Comparison

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